There have been recommendations to improve therapy discovery for epilepsy by incorporating chronic epilepsy models into the preclinical process, but unpredictable seizures and difficulties in maintaining drug levels over prolonged periods have been obstacles to using these animals. We report new protocols in which drugs are administered through a new chronic gastric tube to rats with higher seizure frequencies to minimize these obstacles.

中文翻译：

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用于治疗发现的慢性边缘癫痫模型：提高效率的方案

有人建议通过将慢性癫痫模型纳入临床前过程来改善癫痫的治疗发现，但不可预测的癫痫发作和长期维持药物水平的困难一直是使用这些动物的障碍。我们报告了新的方案，其中药物通过新的慢性胃管对癫痫发作频率较高的大鼠进行管理，以尽量减少这些障碍。