Background: Cutaneous basal cell carcinoma (BCC) has long been associated with UV radiation (UVR) exposure, but data are limited on risks by anatomic site. Methods: We followed 63,912 cancer-free White U.S. radiologic technologists from cohort entry (1983–1989/1994–1998) to exit (date first BCC via 2003–2005 questionnaire). We estimated associations between cumulative ambient UVR and relative/absolute risks of self-reported BCC by anatomic location via Poisson models. Results: For incident first primary BCC in 2,124 subjects (mean follow-up, 16.9 years) log\[excess relative risks\] (ERR) of BCC per unit cumulative ambient UVR = 1.27/MJ cm–2 [95% confidence interval (CI): 0.86–1.68; P trend < 0.001] did not vary by anatomic site ( P = 0.153). However, excess absolute risks of BCC per unit cumulative ambient UVR were large for the head/neck = 5.46/MJ cm–2/104 person-year (95% CI: 2.92–7.36; P trend < 0.001), smaller for the trunk (2.56; 95% CI: 1.26–3.33; P trend = 0.003), with lesser increases elsewhere. There were lower relative risks, but higher absolute risks, for those with Gaelic ancestry ( P < 0.001), also higher absolute risks among those with fair complexion, but relative and absolute risks were not generally modified by other constitutional, lifestyle or medical factors for any anatomic sites. Excess absolute and relative risk was concentrated 5–15 years before time of follow-up. Conclusions: BCC relative and absolute risk rose with increasing cumulative ambient UVR exposure, with absolute risk highest for the head/neck, to a lesser extent in the trunk. Impact: These associations should be evaluated in other White and other racial/ethnic populations along with assessment of possible modification by time outdoors, protective, and behavioral factors.

中文翻译：

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1983-2005 年美国全国队列中按解剖部位划分的终生环境紫外线辐射暴露和基底细胞癌风险

背景：皮肤基底细胞癌 (BCC) 长期以来一直与紫外线辐射 (UVR) 暴露有关，但有关解剖部位风险的数据有限。方法：我们跟踪了 63,912 名无癌症的美国白人放射技师，从队列进入（1983-1989/1994-1998）到退出（通过 2003-2005 问卷调查首次 BCC）。我们通过泊松模型通过解剖位置估计了累积环境 UVR 与自我报告的 BCC 的相对/绝对风险之间的关联。结果：对于 2,124 名受试者（平均随访时间，16.9 年）的首次原发性 BCC，log\[excess relative risk\] (ERR) 每单位累积环境 UVR = 1.27/MJ cm-2 [95% 置信区间 ( CI): 0.86–1.68; P 趋势 < 0.001] 不因解剖部位而异（ P = 0.153）。然而，对于头部/颈部 = 5，每单位累积环境 UVR 的 BCC 超额绝对风险很大。46/MJ cm–2/104 人年（95% CI：2.92–7.36；P 趋势 < 0.001），躯干较小（2.56；95% CI：1.26–3.33；P 趋势 = 0.003），增加幅度较小别处。盖尔血统的人相对风险较低，但绝对风险较高（P < 0.001），肤色白皙者的绝对风险也较高，但相对风险和绝对风险通常不受其他体质、生活方式或医疗因素的影响任何解剖部位。超额绝对和相对风险集中在随访前 5-15 年。结论：BCC 相对和绝对风险随着累积环境 UVR 暴露的增加而上升，头/颈部的绝对风险最高，躯干的程度较小。影响：