An asymmetric formal synthesis of trichodermamides B and C was achieved in 15 steps based on a tyrosine ester chiral-pool approach. Key features of this synthesis include stereoselective construction of a cis-1,2-oxazadecaline core by an acid-mediated tandem deprotection–intramolecular oxy-Michael reaction, oxime ether formation via an N-bromination–elimination sequence, and diene construction by a palladium-catalyzed demonomethylcarbonation.

中文翻译：

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木霉酰胺 B 和 C 的不对称形式合成

基于酪氨酸酯手性池方法，木霉酰胺 B 和 C 的不对称形式合成通过 15 个步骤实现。该合成的关键特征包括通过酸介导的串联脱保护-分子内氧-迈克尔反应立体选择性构建顺式-1,2-氧氮杂萘核心，通过N-溴化-消除序列形成肟醚，以及通过钯构建二烯-催化的去甲甲基碳酸化。