N-glycosylation of immunoglobulin G predicts incident hypertension.,Journal of Hypertension

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N-glycosylation of immunoglobulin G predicts incident hypertension.
Journal of Hypertension ( IF 3.3 ) Pub Date : 2021-07-19 , DOI: 10.1097/hjh.0000000000002963
Domagoj Kifer ₁ , Panayiotis Louca ₂ , Ana Cvetko ₁ , Helena Deriš ₃ , Ana Cindrić ₃ , Harald Grallert _{4,

5} , Annette Peters _{5,

6,

7} , Ozren Polašek ₈ , Olga Gornik ₁ , Massimo Mangino _{2,

9} , Tim D Spector ₂ , Ana M Valdes _{2,

10} , Sandosh Padmanabhan ₁₁ , Christian Gieger _{4,

5} , Gordan Lauc _{1,

3} , Cristina Menni ₂

Affiliation

Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Department of Twin Research, Kings College London, London, UK.
Genos Glycoscience Research Laboratory, Zagreb, Croatia.
Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health.
German Center for Diabetes Research (DZD).
Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health.
LMU Munich, IBE-Chair of Epidemiology, Neuherberg, Germany.
Department of Public Health, University of Split, School of Medicine, Split, Croatia.
NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London.
Academic Rheumatology Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, Nottingham.
University of Glasgow, Glasgow, Scotland, UK.

Glycosylation of immunoglobulin G (IgG) is an important regulator of the immune system and has been implicated in prevalent hypertension.The aim of this study is to investigate whether the IgG glycome begins to change prior to hypertension diagnosis by analysing the IgG glycome composition in a large population-based female cohort with two independent replication samples.

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