To solve the problems caused by irrational land-use, studying the functions of land-use, its changing characteristics, and the relationship between each land-use function will be beneficial for achieving sustainable land development. In this research, we constructed an evaluation framework of multiple land-use functions (LUFs) based on sustainable land-use theory. Specifically, we classified the multiple LUFs into three types: agricultural production function (APF), living function (LVF), and ecological service function (ESF). We then spatialized the economic and social data, and implemented the InVEST (Integrated Valuation of Ecosystem Services and Tradeoffs) model and RUSLE (Revised Universal Soil Loss Equation) model to evaluate each sub-LUF (crop production, aquatic production, woodlands production, livestock production, living space, life quality, water supply, soil conservation, climate regulation, biological conservation) in central China in 2000 and again in 2015. Moreover, by analyzing the changes to LUFs and the relationships between each LUF change, we were able to discern patterns of LUF change in central China. The results show that: 1) 42.12% of total territory in the study area increased their APF from 2000 to 2015, while 43.41% of the lands increased their ESF yet only 8.98% of the lands increased their LVF; 2) in Hubei and Hunan, there was more land with an increase of APF than in Anhui or Jiangxi. The APF in Jiangxi exhibited the greatest decline over time period, the LVF increased more in the provincial capital cities than in other regions, and the ESF expanded more in Jiangxi than in the other provinces; and 3) the changes in APF were significantly and positively correlated with changes in LVF. Additionally, changes in ESF were negatively but non-significantly correlated with changes in APF and LVF.