Despite the crucial role of cell metabolism in biological processes, particularly cell division, metabolic aspects of liver regeneration are not well defined. Better understanding of the metabolic activity governing division of liver cells will provide powerful insights into mechanisms of physiological and pathological liver regeneration. Recent studies have provided evidence that metabolic response to liver failure might be a proximal signal to initiate cell proliferation in liver regeneration. In this review, we highlight how lipids, carbohydrates, and proteins dynamically change and orchestrate liver regeneration. In addition, we discuss translational studies in which metabolic intervention has been used to treat chronic liver diseases (CLDs).

尽管细胞代谢在生物过程，特别是细胞分裂中起着至关重要的作用，但肝脏再生的代谢方面并没有得到很好的定义。更好地了解控制肝细胞分裂的代谢活动将为了解生理和病理肝再生机制提供强有力的见解。最近的研究提供的证据表明，对肝功能衰竭的代谢反应可能是启动肝再生过程中细胞增殖的近端信号。在这篇综述中，我们重点介绍了脂质、碳水化合物和蛋白质如何动态变化和协调肝脏再生。此外，我们还讨论了代谢干预已用于治疗慢性肝病 (CLD) 的转化研究。