Gut hormones secreted from enteroendocrine cells following nutrient ingestion modulate metabolic processes including glucose homeostasis and food intake, and several of these gut hormones are involved in the regulation of the energy demanding process of bone remodelling. Here, we review the gut hormones considered or known to be involved in the gut-bone crosstalk and their role in orchestrating adaptions of bone formation and resorption as demonstrated in cellular and physiological experiments and clinical trials. Understanding the physiology and pathophysiology of the gut-bone axis may identify adverse effects of investigational drugs aimed to treat metabolic diseases such as type 2 diabetes and obesity and new therapeutic candidates for the treatment of bone diseases.

营养摄入后肠内分泌细胞分泌的肠道激素调节代谢过程，包括葡萄糖稳态和食物摄入，其中一些肠道激素参与调节骨骼重塑的能量需求过程。在这里，我们回顾了被认为或已知参与肠-骨串扰的肠道激素，以及它们在协调骨形成和再吸收适应中的作用，如细胞和生理实验和临床试验所示。了解肠-骨轴的生理学和病理生理学可以确定旨在治疗代谢疾病（如 2 型糖尿病和肥胖症）的研究药物的副作用以及治疗骨病的新候选药物。