Background

Recognizing only sharp elevation in a short period of time, the COVID-19 SARS-CoV-2 propagation is more and more marked in the whole world. Induced inflammation afterwards infection engenders a high infiltration of immune cells and cytokines that triggers matrix metalloproteinases (MMPs) activation. These endopeptidases are mediators of the lung extracellular matrix (ECM), a basic element for alveoli structure and gas exchange.

Methods

When immune cells, MMPs, secreted cytokines and several other mediators are gathered a pathological matrix remodeling occurs. This phenomenon tends to tissue destruction in the first place and a pulmonary hypertrophy and fibrosis in the second place.

Findings

After pathological matrix remodeling establishment, pathological diseases take place even after infection state. Since post COVID-19 pulmonary fibrosis is an emerging complication of the disease, there is an urge to better understand and characterize the implication of ECM remodeling during SARS-CoV-2 infection.

Conclusion

Targeting MMPs and their inhibitors could be a probable solution for occurred events since there are many cured patients that remain with severe sequels even after the end of infection.

中文翻译：

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SARS-CoV-2 和病理基质重塑介质

背景

COVID-19 SARS-CoV-2 的传播在全球范围内越来越明显，仅在短时间内出现急剧上升。感染后诱发的炎症会导致免疫细胞和细胞因子的高度浸润，从而触发基质金属蛋白酶 (MMP) 的激活。这些内肽酶是肺细胞外基质 (ECM) 的介质，ECM 是肺泡结构和气体交换的基本元素。

方法

当免疫细胞、基质金属蛋白酶、分泌的细胞因子和其他几种介质聚集在一起时，就会发生病理基质重塑。这种现象首先会导致组织破坏，其次会导致肺肥大和纤维化。

发现

病理基质重塑建立后，即使处于感染状态，也会发生病理疾病。由于 COVID-19 后肺纤维化是该病的一种新并发症，因此迫切需要更好地理解和描述 SARS-CoV-2 感染期间 ECM 重塑的意义。

结论

靶向 MMPs 及其抑制剂可能是解决已发生事件的可能方法，因为许多治愈的患者即使在感染结束后仍留下严重的后遗症。