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The Complex Genetic Basis and Multilayered Regulatory Control of Yeast Pseudohyphal Growth
Annual Review of Genetics ( IF 8.7 ) Pub Date : 2021-11-23 , DOI: 10.1146/annurev-genet-071719-020249
Anuj Kumar 1
Affiliation  

Eukaryotic cells are exquisitely responsive to external and internal cues, achieving precise control of seemingly diverse growth processes through a complex interplay of regulatory mechanisms. The budding yeast Saccharomyces cerevisiae provides a fascinating model of cell growth in its stress-responsive transition from planktonic single cells to a filamentous pseudohyphal growth form. During pseudohyphal growth, yeast cells undergo changes in morphology, polarity, and adhesion to form extended and invasive multicellular filaments. This pseudohyphal transition has been studied extensively as a model of conserved signaling pathways regulating cell growth and for its relevance in understanding the pathogenicity of the related opportunistic fungus Candida albicans, wherein filamentous growth is required for virulence. This review highlights the broad gene set enabling yeast pseudohyphal growth, signaling pathways that regulate this process, the role and regulation of proteins conferring cell adhesion, and interesting regulatory mechanisms enabling the pseudohyphal transition.

中文翻译:


酵母假菌丝生长的复杂遗传基础和多层次调控

真核细胞对外部和内部信号反应灵敏,通过复杂的调控机制相互作用实现对看似多样化的生长过程的精确控制。出芽酵母酿酒酵母在其从浮游单细胞到丝状假菌丝生长形式的应激反应转变中提供了一个迷人的细胞生长模型。在假菌丝生长过程中,酵母细胞会发生形态、极性和粘附性的变化,形成延伸的和侵入性的多细胞细丝。这种假菌丝转变已被广泛研究,作为调节细胞生长的保守信号通路模型及其在了解相关机会性真菌白色念珠菌致病性方面的相关性,其中毒力需要丝状生长。这篇综述重点介绍了使酵母假菌丝生长的广泛基因组、调节这一过程的信号通路、赋予细胞粘附的蛋白质的作用和调节,以及使假菌丝转变的有趣调节机制。

更新日期:2021-11-24
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