Abstract

Objective

The present study evaluated the effects of nicotine concentration (0-10 mg/ml) and flavor (gummy bear vs unflavored) on the subjective experiences of vaporized nicotine in young adult low-dose nicotine (3 mg/ml) ECIG users.

Participants

Eight young adult ECIG users were recruited.

Methods

A single blinded crossover study was used. Participants were instructed to take ten 1.5 second puffs, each separated by 20 seconds. After self-administration, heart rate was recorded, and participants completed the Drug Effects, Direct Effects of Nicotine, and Direct Effects of ECIG questionnaires.

Results

ECIG user’s standard daily nicotine dose influenced the rewarding and aversive effects of nicotine as the 10 mg/ml dose was found to be aversive in this user group. The combination of flavor and nicotine increased the subjective effects of ECIGs.

Conclusions

Flavored e-liquids contribute to the reinforcing properties of nicotine by enhancing the subjective effects, which may lead to continued ECIG use.

中文翻译：

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电子烟对青少年低剂量电子烟使用者主观影响的初步评估：尼古丁剂量和烟油口味的影响

摘要

客观的

本研究评估了尼古丁浓度（0-10 毫克/毫升）和口味（小熊软糖与无味）对年轻成人低剂量尼古丁（3 毫克/毫升）ECIG 使用者的汽化尼古丁主观体验的影响。

参加者

招募了八名年轻的成人 ECIG 用户。

方法

使用单盲交叉研究。参与者被要求抽吸 10 口，每次 1.5 秒，每次间隔 20 秒。自我给药后，记录心率，参与者完成药物效应、尼古丁的直接效应和 ECIG 的直接效应问卷。

结果

ECIG 用户的标准每日尼古丁剂量影响了尼古丁的奖励和厌恶效果，因为发现 10 毫克/毫升剂量在该用户组中是厌恶的。风味和尼古丁的结合增加了 ECIG 的主观效果。

结论

加味电子烟液通过增强主观效果来增强尼古丁的特性，这可能会导致 ECIG 的持续使用。