Studying gold nanoparticle degradation during laser ablation–single particle-inductively coupled plasma mass spectrometry analysis,Journal of Analytical Atomic Spectrometry

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Studying gold nanoparticle degradation during laser ablation–single particle-inductively coupled plasma mass spectrometry analysis
Journal of Analytical Atomic Spectrometry ( IF 3.1 ) Pub Date : 2021-06-29 , DOI: 10.1039/d1ja00150g
Dino Metarapi _{1,

2} , Johannes T. van Elteren ₁ , Martin Šala ₁

Affiliation

Nanoparticle (NP) analysis performed by laser ablation–single particle-inductively coupled plasma mass spectrometry (LA-sp-ICPMS) has recently allowed for multimodal insights to be gained about NPs in biological tissues. In our previous work, NP localizing, sizing and counting, as well as differentiating between the metal NP signal and its ionic form were achieved. In all of these, a low laser fluence (<1 J cm⁻²) was used, as it was observed that higher laser fluences can induce NP degradation, thus invalidating the results. This work is an in-depth study of gold NP (AuNP) degradation upon laser ablation, and provides guidelines for selection of the optimal laser fluence associated with NP analysis in gelatine as a matrix which mimics biological tissues. AuNPs of known size and with a narrow size distribution (CV < 5%) were used to keep track of the measured NP size with changing laser fluence. In addition, optical profilometry was utilized to measure the amount of material ablated as a function of the laser fluence, and provide a more accurate estimation of the NP degradation.

中文翻译：

研究激光烧蚀过程中金纳米颗粒的降解——单颗粒电感耦合等离子体质谱分析

通过激光烧蚀单粒子电感耦合等离子体质谱 (LA-sp-ICPMS) 进行的纳米粒子 (NP) 分析最近允许获得关于生物组织中纳米粒子的多模式见解。在我们之前的工作中，实现了 NP 定位、大小和计数，以及区分金属 NP 信号及其离子形式。在所有这些中，低激光能量密度（<1 J cm ^-2) 被使用，因为观察到更高的激光能量密度会导致 NP 降解，从而使结果无效。这项工作是对激光烧蚀后金 NP (AuNP) 降解的深入研究，并为选择与明胶中 NP 分析相关的最佳激光能量密度作为模拟生物组织的基质提供了指导。已知尺寸且尺寸分布较窄 (CV < 5%) 的 AuNP 用于跟踪随激光能量密度变化而测量的 NP 尺寸。此外，利用光学轮廓测定法来测量作为激光能量密度函数的烧蚀材料量，并提供对 NP 降解的更准确估计。

更新日期：2021-07-21

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