Almost one in four lumpectomies fails to fully remove cancerous tissue from the breast, requiring reoperation. This high failure rate suggests that existing lumpectomy guidance methods are inadequate for allowing surgeons to consistently identify the proper volume of tissue for excision. Current guidance techniques either provide little information about the tumor position or require surgeons to frequently switch between making incisions and manually probing for a marker placed at the lesion site. This article explores the feasibility of thermo-acoustic ultrasound (TAUS) to enable hands-free localization of metallic biopsy markers throughout surgery, which would allow for continuous visualization of the lesion site in the breast without the interruption of surgery. In a TAUS-based localization system, microwave excitations would be transmitted into the breast, and the amplification in microwave absorption around the metallic markers would generate acoustic signals from the marker sites through the thermo-acoustic effect. Detection and ranging of these signals by multiple acoustic receivers on the breast could then enable marker localization through acoustic multilateration.

中文翻译：

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使用热声超声进行活检标记定位，用于乳房肿瘤切除术指导

几乎四分之一的肿块切除术未能从乳房中完全切除癌组织，需要再次手术。这种高失败率表明，现有的乳房肿瘤切除术引导方法不足以让外科医生始终如一地确定合适的组织体积进行切除。当前的引导技术要么提供很少的关于肿瘤位置的信息，要么要求外科医生经常在切口和手动探测放置在病变部位的标记之间切换。本文探讨了热声超声 (TAUS) 在整个手术过程中实现金属活检标记物的免提定位的可行性，这将允许在不中断手术的情况下连续可视化乳房中的病变部位。在基于 TAUS 的本地化系统中，微波激发将传输到乳房中，金属标记周围微波吸收的放大将通过热声效应从标记部位产生声信号。乳房上的多个声学接收器对这些信号的检测和测距可以通过声学多点定位实现标记定位。