Abstract

A simple and efficient procedure for the synthesis of polyhydroquinolines (5a-l) was developed, involving one pot four component Hantzsch condensation of dimedone 1, various substituted benzaldehydes 2, ethyl acetoacetate (EAA) 3 and ammonium acetate 4 in the presence of catalyst praseodymium oxide (Pr₆O₁₁) (10 mol%) in ethanol by irradiated with 150 W tungsten lamp. Mechanistic studies indicated that two possible pathways can be accounted for the four component synthesis of polyhydroquinolines. The key feature of these protocols is environmentally friendly, economic viability high yields, short reaction times, simple work-up procedure.

摘要

开发了一种简单而有效的合成聚氢喹啉 ( 5a-l)的方法，包括在催化剂镨存在下，二甲酮1、各种取代苯甲醛2、乙酰乙酸乙酯 (EAA) 3和乙酸铵4的一锅四组分 Hantzsch 缩合反应通过用 150 W 钨灯照射，在乙醇中的氧化物 (Pr ₆ O ₁₁ ) (10 mol%)。机理研究表明，两种可能的途径可以解释聚氢喹啉的四组分合成。这些协议的主要特点是环境友好、经济可行性高、反应时间短、后处理程序简单。