The cholinergic anti-inflammatory pathway (CAP) is a classic neuroimmune pathway, consisting of the vagus nerve, acetylcholine (ACh)—the pivotal neurotransmitter of the vagus nerve—and its receptors. This pathway can activate and regulate the activities of immune cells, inhibit cell proliferation and differentiation, as well as suppress cytokine release, thereby playing an anti-inflammatory role, and widely involved in the occurrence and development of various diseases; recent studies have demonstrated that the CAP may be a new target for the treatment of autoimmune rheumatic diseases. In this review, we will summarize the latest progress with the view of figuring out the role of the cholinergic pathway and how it interacts with inflammatory reactions in several autoimmune rheumatic diseases, and many advances are results from a wide range of experiments performed in vitro and in vivo.

中文翻译：

---

胆碱能抗炎通路在自身免疫性风湿病中的作用

胆碱能抗炎通路 (CAP) 是一种经典的神经免疫通路，由迷走神经、乙酰胆碱 (ACh)（迷走神经的关键神经递质）及其受体组成。该通路可以激活和调节免疫细胞的活性，抑制细胞增殖和分化，抑制细胞因子的释放，从而起到抗炎作用，广泛参与各种疾病的发生发展；最近的研究表明，CAP可能是治疗自身免疫性风湿病的新靶点。在这篇综述中，我们将从了解胆碱能通路的作用以及它如何与几种自身免疫性风湿病中的炎症反应相互作用的角度总结最新进展，