Biopolymers are a promising alternative to petroleum-based plastic raw materials. They are bio-based, non-toxic and degradable under environmental conditions. In addition to the homopolymer poly(3-hydroxybutyrate) (PHB), there are a number of co-polymers that have a broad range of applications and are easier to process in comparison to PHB. The most prominent representative from this group of bio-copolymers is poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this article, we show a new kinetic model that describes the PHBV production from fructose and propionic acid in Cupriavidus necator (C. necator). The developed model is used to analyze the effects of process parameter variations such as the CO${}_2$ amount in the exhaust gas and the feed rate. The presented model is a valuable tool to improve the microbial PHBV production process. Due to the coupling of CO${}_2$ online measurements in the exhaust gas to the biomass production, the model has the potential to predict the composition and the current yield of PHBV in the ongoing process.

中文翻译：

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使用果糖和丙酸盐作为碳源的生物共聚物聚（3-羟基丁酸酯-co-3-羟基戊酸酯）生产的高级动力学建模

生物聚合物是石油基塑料原料的有前途的替代品。它们是生物基的，无毒且在环境条件下可降解。除了均聚物聚（3-羟基丁酸酯）（PHB）之外，还有许多共聚物具有广泛的应用范围，并且与 PHB 相比更易于加工。来自该组的生物共聚物的最突出的代表是聚（3-羟基丁酸酯共-3-羟基戊酸酯）（PHBV）。在这篇文章中，我们展示了一个新的动力学模型，该模型描述了在Cupriavidus necator ( C. necator ) 中从果糖和丙酸产生 PHBV 。开发的模型用于分析工艺参数变化的影响，例如 CO${}_2$废气中的量和进料速度。所提出的模型是改进微生物 PHBV 生产过程的宝贵工具。由于CO的耦合${}_2$ 在线测量生物质生产的废气，该模型有可能预测正在进行的过程中 PHBV 的成分和当前产量。