Point-of-care testing (POCT) is becoming a hot research topic that allows rapid, on-site, and non-professional measurements outside the central laboratory. The micro-fabricated devices prepared by various micro-machining technologies have shown the advantages of low reagent consumption, high-throughput samples, and wearability. This review presents the recent progress of electrochemical biosensors based on various micro-fabricated devices for POCT and the corresponding electrochemical techniques. Signal amplification strategies based on enzyme and nanotechnology are also illustrated for the more sensitive POCT applications of these micro-fabricated devices. Consequently, the trends and challenges of electrochemical biosensors based on micro-fabricated devices in POCT diagnosis are discussed.

中文翻译：

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基于微型制造设备的即时检测电化学生物传感器：综述

即时检测 (POCT) 正在成为一个热门研究课题，它允许在中心实验室之外进行快速、现场和非专业测量。各种微加工技术制备的微加工装置显示出试剂消耗低、样品通量高、可穿戴等优点。本综述介绍了基于用于 POCT 的各种微制造器件的电化学生物传感器的最新进展以及相应的电化学技术。还说明了基于酶和纳米技术的信号放大策略，用于这些微制造设备的更敏感的 POCT 应用。因此，讨论了基于微加工器件的电化学生物传感器在 POCT 诊断中的发展趋势和挑战。