Conjunctival papillomas are common tumors that exhibit an exophytic growth pattern, comprised of multiple filiform fronds of squamous epithelium that contain fibrovascular cores. The inverted (endophytic) variety of papilloma, often termed "Schneiderian," rarely occurs on the conjunctiva, with only 15 cases reported to date. Endophytic and exophytic papillomas are well described arising in the sinonasal Schneiderian epithelium where a low rate of malignant transformation may occur in the endophytic type; malignant transformation in exophytic sinonasal papillomas is exceedingly rare. The authors describe 2 cases of exophytic conjunctival papillomas with the morphology of a sinonasal or Schneiderian-type papilloma. Both were pink, sessile acquired growths in women in the sixth decade of life involving the inferior conjunctival fornix or nasal limbus. Nonkeratinizing squamous epithelium along with numerous goblet cells, intraepithelial mucinous cysts, and microabscesses were present. Immunohistochemistry showed reactivity for cytokeratin 7 and wild-type staining for p16 and p53, paralleling the findings in common conjunctival papillomas; both were also driven by low-risk human papillomavirus.

中文翻译：

---

结膜外生性施奈德型乳头状瘤：罕见。

结膜乳头状瘤是常见的肿瘤，表现出外生性生长模式，由含有纤维血管核心的鳞状上皮的多个丝状叶组成。倒置（内生）乳头状瘤，通常称为“施奈德型”，很少发生在结膜上，迄今为止仅报告了 15 例。内生性和外生性乳头状瘤在鼻窦施奈德氏上皮中被充分描述，其中内生型可能发生较低的恶变率；外生性鼻窦乳头状瘤恶变极为罕见。作者描述了 2 例外生性结膜乳头状瘤，其形态为鼻窦或施奈德型乳头状瘤。两者都是粉红色的、无蒂的后天性增生，发生在六十多岁的女性中，累及下结膜穹窿或鼻缘。存在非角化鳞状上皮以及大量杯状细胞、上皮内粘液囊肿和微脓肿。免疫组织化学显示细胞角蛋白 7 的反应性以及 p16 和 p53 的野生型染色，与常见结膜乳头状瘤的结果相似；两者也是由低风险人乳头瘤病毒驱动的。