Increased plasma levels of asymmetric dimethylarginine can be encountered in chronic inflammatory disease, liver damage, renal failure, and multiple organ failure. In addition, an association between circulating asymmetric dimethylarginine levels and all-cause mortality has been reported. Male Sprague-Dawley rats, postnatal day 17 ± 1, received continuous asymmetric dimethylarginine infusion via an intraperitoneal pump. Spatial performance and dorsal hippocampal asymmetric dimethylarginine and brain-derived neurotrophic factor (BDNF) levels were examined, and the effect of resveratrol was tested. A 4-week continuous asymmetric dimethylarginine infusion in young male rats caused spatial deficits, increased asymmetric dimethylarginine levels, and decreased BDNF expression in the dorsal hippocampus. Increased oxidative stress and altered molecules in the dorsal hippocampus linked to asymmetric dimethylarginine and BDNF functions were detected. Resveratrol protected against these effects, reversing spatial deficits, and reducing the changes in the dorsal hippocampal asymmetric dimethylarginine and BDNF levels.

中文翻译：

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在循环不对称二甲基精氨酸增加的年轻大鼠中，白藜芦醇可防止空间缺陷并挽救混乱的海马不对称二甲基精氨酸和脑源性神经营养因子水平。

慢性炎症性疾病、肝损伤、肾衰竭和多器官衰竭可能会导致血浆不对称二甲基精氨酸水平升高。此外，据报道，循环不对称二甲基精氨酸水平与全因死亡率之间存在关联。雄性 Sprague-Dawley 大鼠，出生后第 17 ± 1 天，通过腹膜内泵接受连续不对称二甲基精氨酸输注。检查了空间表现和背侧海马不对称二甲基精氨酸和脑源性神经营养因子（BDNF）水平，并测试了白藜芦醇的效果。年轻雄性大鼠连续 4 周不对称二甲基精氨酸输注会导致空间缺陷，不对称二甲基精氨酸水平增加，背侧海马 BDNF 表达减少。检测到背侧海马氧化应激增加以及与不对称二甲基精氨酸和 BDNF 功能相关的分子改变。白藜芦醇可以防止这些影响，逆转空间缺陷，并减少背侧海马不对称二甲基精氨酸和 BDNF 水平的变化。