Microtubule affinity regulating kinase 4 (MARK4), an important member of the serine/threonine kinase family, regulates the phosphorylation of microtubule-associated proteins and thus modulates microtubule dynamics. In human atherosclerotic lesions, the expression of MARK4 is significantly increased. Recently, accumulating evidence suggests that MARK4 exerts a proatherogenic effect via regulation of lipid metabolism (cholesterol, fatty acid, and triglyceride), inflammation, cell cycle progression and proliferation, insulin signaling, and glucose homeostasis, white adipocyte browning, and oxidative stress. In this review, we summarize the latest findings regarding the role of MARK4 in the pathogenesis of atherosclerosis to provide a rationale for future investigation and therapeutic intervention.

中文翻译：

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微管亲和力调节激酶4：动脉粥样硬化发病机制中的一个有希望的靶点

微管亲和力调节激酶 4 (MARK4) 是丝氨酸/苏氨酸激酶家族的重要成员，可调节微管相关蛋白的磷酸化，从而调节微管动力学。在人类动脉粥样硬化病变中，MARK4的表达显着增加。最近，越来越多的证据表明 MARK4 通过调节脂质代谢（胆固醇、脂肪酸和甘油三酯）、炎症、细胞周期进程和增殖、胰岛素信号传导和葡萄糖稳态、白色脂肪细胞褐变和氧化应激来发挥促动脉粥样硬化的作用。在这篇综述中，我们总结了关于 MARK4 在动脉粥样硬化发病机制中作用的最新发现，为未来的研究和治疗干预提供了依据。