Emerging roles of angiopoietin-like proteins in inflammation: Mechanisms and potential as pharmacological targets,Journal of Cellular Physiology

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Emerging roles of angiopoietin-like proteins in inflammation: Mechanisms and potential as pharmacological targets
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2021-07-21 , DOI: 10.1002/jcp.30534
Jing Yang ₁ , Qiu-Yi Song ₁ , Shu-Xuan Niu ₁ , Hui-Jing Chen ₁ , Robert B Petersen ₂ , Yu Zhang ₁ , Kun Huang ₁

Affiliation

Angiopoietin-like proteins (ANGPTLs), a family of eight secreted glycoproteins termed ANGTPL1-8, are involved in angiogenesis, lipid metabolism, cancer progression, and inflammation. Their roles in regulating lipid metabolism have been intensively studied, as some ANGPTLs are promising pharmacological targets for hypertriglyceridemia and associated cardiovascular disease. Recently, the emerging roles of ANGPTLs in inflammation have attracted great attention. First, elevated levels of multiple circulating ANGPTLs in inflammatory diseases make them potential disease biomarkers. Second, multiple ANGPTLs regulate acute or chronic inflammation via various mechanisms, including triggering inflammatory signaling through their action as ligands for integrin or forming homo- /hetero-oligomers to regulate signal transduction via extra- or intracellular mechanisms. As dysregulation of the inflammatory response is a critical trigger in many diseases, understanding the roles of ANGPTLs in inflammation will aid in drug/therapy development. Here, we summarize the roles, mechanisms, and potential therapeutic values for ANGPTLs in inflammation and inflammatory diseases.

中文翻译：

血管生成素样蛋白在炎症中的新作用：机制和作为药理学靶点的潜力

血管生成素样蛋白 (ANGPTLs) 是一个由八种分泌糖蛋白组成的家族，称为 ANGTPL1-8，参与血管生成、脂质代谢、癌症进展和炎症。它们在调节脂质代谢中的作用已被深入研究，因为一些 ANGPTL 是高甘油三酯血症和相关心血管疾病的有希望的药理学靶点。最近，ANGPTLs 在炎症中的新兴作用引起了人们的极大关注。首先，炎症性疾病中多种循环 ANGPTL 水平升高使其成为潜在的疾病生物标志物。其次，多种 ANGPTLs 通过各种机制调节急性或慢性炎症，包括通过它们作为整合素配体的作用触发炎症信号传导或形成同源/异源寡聚体以通过细胞外或细胞内机制调节信号转导。由于炎症反应的失调是许多疾病的关键触发因素，因此了解 ANGPTL 在炎症中的作用将有助于药物/疗法的开发。在这里，我们总结了 ANGPTLs 在炎症和炎症疾病中的作用、机制和潜在的治疗价值。

更新日期：2021-07-21

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