Fast acting topical hemostatic agents play a key role in hemorrhage control. Retarding fibrinolysis is also critical in improving coagulation, thereby expanding chances of survival. The purpose of the present work was to investigate the physical properties, loading capacity and hemostatic efficacy of newly developed nanoclay microsphere frameworks (NMFs) loaded with tranexamic acid (TA), as antifibrinolytic agent. Nanoclay compositions were prepared with increasing levels of TA. Results showed that TA was successfully incorporated into the nanoclay structure and released when solvated with ethanol. Both doped and undoped NMFs significantly decreased activated partial thromboplastin time and increased clot stiffness, which was attributed to significantly thinner fibrin fibers and a denser clot structure.

中文翻译：

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载氨甲环酸止血纳米粘土微球骨架


速效局部止血剂在控制出血中发挥着关键作用。延缓纤维蛋白溶解对于改善凝血功能也至关重要，从而增加生存机会。本工作的目的是研究新开发的负载氨甲环酸（TA）作为抗纤溶剂的纳米粘土微球框架（NMF）的物理性质、负载能力和止血功效。制备具有增加的TA水平的纳米粘土组合物。结果表明，TA 成功融入纳米粘土结构中，并在与乙醇溶剂化时释放。掺杂和未掺杂的 NMF 均显着降低了活化的部分凝血活酶时间并增加了凝块硬度，这归因于显着更细的纤维蛋白纤维和更致密的凝块结构。