1'-Acetoxychavicol acetate, a potent transient receptor potential ankyrin 1 agonist derived from Thai ginger, prevents visceral fat accumulation in mice fed with a high-fat and high-sucrose diet.,Bioscience, Biotechnology, and Biochemistry

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1'-Acetoxychavicol acetate, a potent transient receptor potential ankyrin 1 agonist derived from Thai ginger, prevents visceral fat accumulation in mice fed with a high-fat and high-sucrose diet.
Bioscience, Biotechnology, and Biochemistry ( IF 1.4 ) Pub Date : 2021-09-22 , DOI: 10.1093/bbb/zbab131
Tatsunori Ikeya ₁ , Yuko Terada _{1,

2} , Yasujiro Morimitsu ₃ , Kikue Kubota ₃ , Keisuke Ito _{1,

2} , Tatsuo Watanabe _{1,

2}

Affiliation

1'-Acetoxychavicol acetate (ACA) is found in Thai ginger (Alpinia galanga) and is a powerful agonist of transient receptor potential ankyrin 1 (TRPA1). In a diet-induced obesity mouse model, ACA reduced fat deposition. Sympathetic nerve activation was also indicated in the ACA-fed group. This study is expected to promote the utilization of food containing TRPA1 agonists to treat obesity.

中文翻译：

1'-Acetoxychavicolacetate 是一种源自泰国生姜的有效瞬时受体电位锚蛋白 1 激动剂，可防止高脂肪和高糖饮食喂养的小鼠内脏脂肪堆积。

1'-Acetoxychavicolacetate (ACA) 存在于泰国生姜 (Alpinia galanga) 中，是瞬时受体电位锚蛋白 1 (TRPA1) 的强效激动剂。在饮食诱导的肥胖小鼠模型中，ACA 减少了脂肪沉积。 ACA 喂养组也显示出交感神经激活。这项研究有望促进含有 TRPA1 激动剂的食品用于治疗肥胖症。

更新日期：2021-07-19

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