Generally, volatile thiols are hard to be measured with electrospray-ionization-type LC-MS due to the volatility. Therefore, we here evaluated the pretreatment of their S-bimanyl derivatization by monobromobimane to enable the detection as nonvolatile derivative. Consequently, we successfully developed the convenient and efficient method through the quantitative analysis of 2-furanmethanethiol (volatile thiol odorant of coffee aroma) in coffee bean.

中文翻译：

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通过集成硫醇特异性衍生化，开发以 LC-ESI-MS 作为非挥发性衍生物的挥发性硫醇化合物的定量分析方法。

通常，挥发性硫醇由于挥发性而难以用电喷雾电离型 LC-MS 测量。因此，我们在此评估了通过单溴二甲双胍对其 S-联二甲基衍生化的预处理，以使其能够检测为非挥发性衍生物。因此，我们通过定量分析咖啡豆中的 2-呋喃甲硫醇（咖啡香气的挥发性硫醇气味剂），成功开发了一种简便高效的方法。