Lysosomes (vacuoles in yeast) are master regulators of metabolism and protein turnover, but how they degrade their own resident proteins is unclear. Recently, multiple models have been proposed explaining yeast vacuole protein sorting, but the role of the ESCRT pathway was unclear. In this JCB issue, work from Yang et al. (https://doi.org/10.1083/jcb.202012104) highlights how the ESCRT pathway localizes to the vacuole surface to execute protein sorting of its resident proteins.

中文翻译：

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液泡 ESRT 如何将其自身蛋白质运送到最终目的地

溶酶体（酵母中的液泡）是新陈代谢和蛋白质周转的主要调节者，但它们如何降解自身的常驻蛋白质尚不清楚。最近，人们提出了多种模型来解释酵母液泡蛋白质分选，但 ESCRT 通路的作用尚不清楚。在本期 JCB 中，Yang 等人的工作。(https://doi.org/10.1083/jcb.202012104) 强调了 ESCRT 通路如何定位于液泡表面以对其驻留蛋白执行蛋白质分选。