Amyloid proteins can aggregate into insoluble fibrils and form amyloid deposits in the human brain, which is the hallmark of many neurodegenerative diseases. Promising strategies toward pathological amyloid proteins and deposition include investigating inhibitors that can disrupt amyloid aggregation or induce misfolding protein degradation. In this review, recent progress of peptide-based inhibitors, including amyloid sequence-derived inhibitors, designed peptides, and peptide mimics, is highlighted. Based on the increased understanding of peptide design and precise amyloid structures, these peptides exhibit advanced inhibitory activities against fibrous aggregation as well as enhanced druggability.

中文翻译：

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用于破坏和降解淀粉样蛋白的肽。

淀粉样蛋白可以聚集成不溶性原纤维并在人脑中形成淀粉样蛋白沉积物，这是许多神经退行性疾病的标志。针对病理性淀粉样蛋白和沉积的有希望的策略包括研究可以破坏淀粉样蛋白聚集或诱导错误折叠蛋白降解的抑制剂。在这篇综述中，重点介绍了基于肽的抑制剂的最新进展，包括淀粉样蛋白序列衍生的抑制剂、设计的肽和肽模拟物。基于对肽设计和精确淀粉样蛋白结构的深入了解，这些肽表现出对纤维聚集的先进抑制活性以及增强的成药性。