The clinical applications of magnesium (Mg) alloys remain a challenge due to their corrosion rate and toxicity problems. Herein, we report a biodegradable polyacrylate copolymer coating for enhancement of Mg alloy's anticorrosion performance and biocompatibility. Specifically, the biodegradable polyacrylate copolymer was first synthesized through the free-radical ring-opening copolymerization of 2-methylene-1,3-dioxepane (MDO), vinyl acetate (VAc), 7-(2-methacryloyloxyethoxy)-4-methylcoumarin (CMA), and dopamine methacrylamide (DMA). The poly(MDO-co-VAc-co-CMA-co-DMA) (PMVCD) coating was then applied on the surface of Mg alloy using electrophoretic deposition (EPD) and crosslinked under UV irradiation. The photo-crosslinking ability and biodegradability of PMVCD coating was provided by the CMA and MDO moieties, respectively. Potentiodynamic polarization, electrochemical impedance spectroscopy and in vitro degradation test demonstrated that the corrosion rate of PMVCD-coated Mg alloy was significantly decreased. Additionally, the enhanced cytocompatibility of PMVCD-coated Mg alloy was confirmed by in vitro cytotoxicity test.

由于其腐蚀速率和毒性问题，镁 (Mg) 合金的临床应用仍然是一个挑战。在此，我们报告了一种可生物降解的聚丙烯酸酯共聚物涂层，用于提高镁合金的防腐性能和生物相容性。具体而言，首先通过2-亚甲基-1,3-二氧杂环庚烷（MDO）、乙酸乙烯酯（VAc）、7-（2-甲基丙烯酰氧基乙氧基）-4-甲基香豆素的自由基开环共聚合成了可生物降解的聚丙烯酸酯共聚物（ CMA) 和多巴胺甲基丙烯酰胺 (DMA)。聚(MDO- co- VAc- co- CMA- co然后使用电泳沉积 (EPD) 将 -DMA) (PMVCD) 涂层施加到镁合金表面并在紫外线照射下交联。PMVCD 涂层的光交联能力和生物降解能力分别由 CMA 和 MDO 部分提供。动电位极化、电化学阻抗谱和体外降解试验表明，PMVCD涂层镁合金的腐蚀速率显着降低。此外，体外细胞毒性试验证实了 PMVCD 涂层镁合金增强的细胞相容性。