Exposure to stressful experiences is often accompanied by suppressing pain perception, referred to as stress-induced analgesia. The neuropeptides orexins are essential in regulating the mechanism that responds to stressful and painful stimuli. Meanwhile, the ventral tegmental area (VTA), as a part of descending pain inhibitory system, responds to noxious stimuli. This study aimed to investigate the role of intra-VTA administration of orexin receptor antagonists on stress-induced antinociceptive responses in the animal model of acute pain.

中文翻译：

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食欲素系统在应激性镇痛中的调节作用：腹侧被盖区的参与

暴露于压力经历通常伴随着抑制疼痛感，称为压力诱发的镇痛。神经肽食欲素对于调节对压力和疼痛刺激的反应机制至关重要。同时，腹侧被盖区 (VTA) 作为下行疼痛抑制系统的一部分，对有害刺激做出反应。本研究旨在研究 VTA 内注射食欲素受体拮抗剂对急性疼痛动物模型中应激诱导的镇痛反应的作用。