Birth weight (BW) and days to 100 kg (D100) are important economic traits that are both affected by polygenes. However, the genetic architecture of these quantitative traits is still elusive. Genotyping-by-sequencing (GBS) data containing a large number of single nucleotide polymorphisms (SNPs) have become a powerful tool in genomic analysis. To better understand their complex genetic structure, a total of 600 Yorkshire pigs were sequenced using GBS technology. After quality control, 279 787 SNPs were generated for subsequent genome-wide association study (GWAS). A total of 30 genome-wide SNPs (P<1.79E–07) were identified for D100. Furthermore, a total of 22 and 2 suggestive SNPs (P<3.57E–06) were detected for D100 and BW, respectively. Of these, one locus located on SSC12 (position: 46 226 512 bp) were evaluated to affect both BW and D100 in Yorkshire pigs, indicating the pleiotropism in different traits. Considering the function of candidate genes, two genes, NSRP1 and DOCK7, were suggested as the most promising candidate genes involved in growth traits. Thus, use of GBS is able to identify novel variants and potential candidate genes for BW and D100, and provide an opportunity for improving pig growth traits using genomic selection in pigs.

出生体重 (BW) 和 100 公斤天数 (D100) 是受多基因影响的重要经济性状。然而，这些数量性状的遗传结构仍然难以捉摸。包含大量单核苷酸多态性 (SNP) 的基因分型测序 (GBS) 数据已成为基因组分析的有力工具。为了更好地了解它们复杂的遗传结构，使用 GBS 技术对总共 600 头约克夏猪进行了测序。质量控制后，产生了 279 787 个 SNP，用于随后的全基因组关联研究 (GWAS)。D100 共鉴定出 30 个全基因组 SNP（P<1.79E-07）。此外，对于 D100 和 BW，总共检测到 22 个和 2 个提示性 SNP（P<3.57E-06）。其中，一个位点位于 SSC12（位置：46 226 512 bp) 被评估影响约克夏猪的 BW 和 D100，表明不同性状的多效性。考虑候选基因的功能，两个基因，NSRP1和DOCK7被认为是与生长性状相关的最有希望的候选基因。因此，使用 GBS 能够鉴定 BW 和 D100 的新变体和潜在候选基因，并为使用猪的基因组选择改善猪的生长性状提供机会。