Mitochondrial activity is becoming an inherent aspect of cellular protein homeostasis (proteostasis). In this issue, Schlagowski et al (2021) report on the attractive notion that modulating mitochondrial protein import activity stimulates protein aggregate clearance in the cytosol, thereby affecting cytosolic proteostasis and its collapse observed in neurodegenerative diseases.

中文翻译：

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抑制有毒聚集体：让 MIA 来做吧！

线粒体活性正在成为细胞蛋白质稳态（proteostasis）的固有方面。在本期中，Schlagowski等人(2021) 报告了一个有吸引力的观点，即调节线粒体蛋白质输入活性会刺激细胞溶质中的蛋白质聚集体清除，从而影响细胞溶质蛋白质稳态及其在神经退行性疾病中观察到的崩溃。