Journal of Cardiovascular Translational Research ( IF 2.4 ) Pub Date : 2021-07-19 , DOI: 10.1007/s12265-021-10158-0 Elona Rrapo Kaso 1 , Jonathan A Pan 1 , Michael Salerno 1, 2, 3 , Alexandra Kadl 4 , Chad Aldridge 5 , Ziv J Haskal 2 , Jamie L W Kennedy 6 , Sula Mazimba 1 , Andrew D Mihalek 4 , Nicholas R Teman 7 , Jay Giri 8 , Herbert D Aronow 9 , Aditya M Sharma 1
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Venoarterial extracorporeal membrane oxygenation (ECMO) has been used to treat acute massive pulmonary embolism (PE) patients. However, the incremental benefit of ECMO to standard therapy remains unclear. Our meta-analysis objective is to compare in-hospital mortality in patients treated for acute massive PE with and without ECMO. The National Library of Medicine MEDLINE (USA), Web of Science, and PubMed databases from inception through October 2020 were searched. Screening identified 1002 published articles. Eleven eligible studies were identified, and 791 patients with acute massive PE were included, of whom 270 received ECMO and 521 did not. In-hospital mortality was not significantly different between patients treated with vs. without ECMO (OR = 1.24 [95% CI, 0.63–2.44], p = 0.54). However, these findings were limited by significant study heterogeneity. Additional research will be needed to clarify the role of ECMO in massive PE treatment.
Graphical abstract
中文翻译：
急性大块肺栓塞的静脉动脉体外膜氧合：荟萃分析和行动呼吁
静脉动脉体外膜肺氧合 (ECMO) 已用于治疗急性大块肺栓塞 (PE) 患者。然而，ECMO 对标准治疗的增量益处仍不清楚。我们的荟萃分析目的是比较接受和不接受 ECMO 治疗的急性大面积肺栓塞患者的院内死亡率。搜索了国家医学图书馆 MEDLINE（美国）、Web of Science 和 PubMed 数据库，从创建到 2020 年 10 月。筛选确定了 1002 篇发表的文章。确定了 11 项符合条件的研究，共纳入 791 名急性大面积肺栓塞患者，其中 270 名接受了 ECMO，521 名未接受。住院死亡率在接受 ECMO 治疗与未接受 ECMO 治疗的患者之间没有显着差异（OR = 1.24 [95% CI, 0.63–2.44]，p= 0.54）。然而，这些发现受到显着研究异质性的限制。需要更多的研究来阐明 ECMO 在大规模 PE 治疗中的作用。
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