Commensal flora colonization during hospitalization by bacteria is the first step for nosocomial infections while antibiotic resistance reduces therapeutic options. In aim to control this phenomenon, we initiated this study to describe the impact of hospitalization on colonization by methicillin-resistant Staphylococcus aureus in the surgical department of 03 health facilities in the Ndé division, West-Cameroon. This study was carried out on patients admitted for surgery in 03 health facilities of the Ndé division, West-Cameroon (District Hospital of Bangangté, Protestant Hospital of Bangwa and Cliniques Universitaires des Montagnes). After obtaining ethical clearance and authorizations, nasal swabs were performed at admission and discharge, with the aim of isolating bacteria and performing their antibiotic susceptibility tests. Informations on each participant's antibiotic therapy were recorded. Laboratory investigations were carried out according to standard protocols (CASFM, 2019). The most commonly used antibiotics were β-lactams. A total of 104 nasal swabs were performed on 52 patients who agreed to participate to the study. From the analysis, 110 (57 at admission versus 53 at discharge) Staphylococcus isolates were obtained. Overall, susceptibility testing showed that antibiotic resistance rates were higher at discharge than at admission; with significant differences between the susceptibility profiles obtained at admission and discharge for β-lactams and not significant for fluoroquinolones and aminoglycosides. Globally, frequency of nasal carriage of methicillin-resistant Staphylococcus aureus at discharge 16 (30.77%) was significantly higher than at admission 07 (13.46%) with Chi-2 = 4.52 and p = 0.0335. The high rates of antibiotic resistance of bacteria isolated at discharge compared to those isolated at admission obtained in the present investigation, highlights the important role that hospitalization plays in the selection and dissemination of methicillin-resistant Staphylococcus aureus and colonization by these bacteria in health structures of Ndé division. As a result, further investigations to find the factors that promote this phenomenon should be carried out.

中文翻译：

---

西喀麦隆 Ndé 区 03 家卫生机构外科部耐甲氧西林金黄色葡萄球菌的住院和定植

细菌在住院期间的共生菌群定植是医院感染的第一步，而抗生素耐药性则减少了治疗选择。为了控制这种现象，我们发起了这项研究，以描述住院治疗对西喀麦隆 Ndé 区 03 卫生机构外科部门耐甲氧西林金黄色葡萄球菌定植的影响。这项研究是针对在西喀麦隆 Ndé 分部的 03 家医疗机构（Bangangté 地区医院、Bangwa 新教医院和 Cliniques Universitaires des Montagnes）入院接受手术的患者进行的。在获得伦理许可和授权后，在入院和出院时进行鼻拭子检查，目的是分离细菌并进行抗生素药敏试验。记录了每位参与者抗生素治疗的信息。实验室调查是根据标准协议（CASFM，2019）进行的。最常用的抗生素是β-内酰胺类。对同意参与该研究的 52 名患者共进行了 104 次鼻拭子检查。从分析中，获得了 110 个（入院时 57 个，出院时 53 个）葡萄球菌分离株。总体而言，药敏试验显示出院时的抗生素耐药率高于入院时；入院和出院时获得的 β-内酰胺类药物敏感性差异显着，而氟喹诺酮类和氨基糖苷类药物的敏感性不显着。在全球范围内，出院时经鼻携带耐甲氧西林金黄色葡萄球菌的频率 16 (30. 77%) 显着高于 07 年入院时 (13.46%)，Chi-2 = 4.52 和 p = 0.0335。与本调查中获得的出院时分离出的细菌相比，出院时分离出的细菌的抗生素耐药率高，突出了住院在耐甲氧西林金黄色葡萄球菌的选择和传播以及这些细菌在健康结构中定植方面的重要作用。恩德师。因此，应进一步调查以找出促成这种现象的因素。强调了住院治疗在耐甲氧西林金黄色葡萄球菌的选择和传播以及这些细菌在 Ndé 部门的健康结构中定植方面的重要作用。因此，应进一步调查以找出促成这种现象的因素。强调了住院治疗在耐甲氧西林金黄色葡萄球菌的选择和传播以及这些细菌在 Ndé 部门的健康结构中定植方面的重要作用。因此，应进一步调查以找出促成这种现象的因素。