Introduction Obesity treatment guidelines suggest moderate-intensity continuous training (MICT), but the patient’s compliance to this indication remains low. High-intensity interval training (HIIT) is a time sparing training mode whose metabolic effects are not clear. This study aimed to determine whether a 12-week HIIT was more effective than MICT for weight loss in obese adults. Methods 44 obese subjects were randomised and trained with isoenergetic treadmill exercises for 12 weeks: MICT (60% of maximal oxygen peak, VO2peak) or HIIT (3–7 repetition of 3 min 100% of VO2peak interspersed by 1.5 min 50% of VO2peak). The primary outcome was a change in body weight; the secondary outcomes were changes in body composition, blood pressure, lipid profile, glycaemia, insulin and VO2peak. Results 32 subjects (53% male, mean age: 38.5 years, mean body mass index: 35.5 kg/m2) completed the trial. MICT and HIIT showed comparable effect within groups in weight loss (−6.0 kg (−9.0 kg to −3.0 kg) vs −5.7 kg (−8.3 kg to −3.1 kg)), changes in fat mass (−2.9% (−4.4% to −1.4%) vs −3.6% (−5.9% to −1.2%)), fat free mass (−5.3% (−7.8% to −2.8%) vs −5.5% (−8.3% to −2.6%)), diastolic blood pressure (−5.5 mm Hg (−10.6 mm Hg to −0.3 mm Hg) vs −5.8 mm Hg (−11.3 mm Hg to −0.3 mm Hg)) and low-density lipoprotein cholesterol (−16.4 mg/dL (−30.8 mg/dL to −2.0 mg/dL) vs −14.7 mg/dL (−25.6 mg/dL to −3.8 mg/dL)). There was a significant change between groups in VO2peak (HIIT: +461.6 mL (329.3‒593.8 mL); MICT: +170.5 mL (86.7–254.4 mL); p<0001) and duration of sessions (HIIT: 35.0 min (31.7 ‒35.6 min); MICT: 46.5 min (40.2‒48.3 min); p<0.001). No significant changes in systolic blood pressure, high-density lipoprotein cholesterol, triglycerides, glycaemia or plasma insulin were observed. Conclusions In healthy adults with obesity, HIIT compared with MICT induced similar weight loss and cardiovascular risk factors improvement but resulted in a larger increase in cardiorespiratory fitness over a shorter period. Data are available upon reasonable request.

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高强度间歇训练对肥胖成人减肥的有效性：一项随机对照非劣效性试验

简介 肥胖治疗指南建议进行中等强度的持续训练 (MICT)，但患者对这一适应症的依从性仍然很低。高强度间歇训练（HIIT）是一种代谢效果尚不明确的省时训练模式。本研究旨在确定 12 周 HIIT 是否比 MICT 更有效地减轻肥胖成人的体重。方法 44 名肥胖受试者随机接受等能跑步机运动训练 12 周：MICT（最大氧峰值的 60%，VO2peak）或 HIIT（3-7 次重复 3 分钟 100% VO2peak 穿插 1.5 分钟 VO2peak 的 50%） . 主要结果是体重的变化；次要结果是身体成分、血压、血脂、血糖、胰岛素和 VO2peak 的变化。结果 32 名受试者（53% 男性，平均年龄：38.5 岁，平均体重指数：35.5 kg/m2) 完成试验。MICT 和 HIIT 在体重减轻（-6.0 kg（-9.0 kg 至 -3.0 kg）与 -5.7 kg（-8.3 kg 至 -3.1 kg））、脂肪量变化（-2.9%（-4.4 % 至 -1.4%）对比 -3.6%（-5.9% 至 -1.2%）），无脂肪质量（-5.3%（-7.8% 至 -2.8%）对比 -5.5%（-8.3% 至 -2.6%） )、舒张压（-5.5 毫米汞柱（-10.6 毫米汞柱至 -0.3 毫米汞柱）对比 -5.8 毫米汞柱（-11.3 毫米汞柱至 -0.3 毫米汞柱））和低密度脂蛋白胆固醇（-16.4 毫克/分升） （-30.8 mg/dL 至 -2.0 mg/dL）对比 -14.7 mg/dL（-25.6 mg/dL 至 -3.8 mg/dL））。VO2peak（HIIT：+461.6 mL（329.3-593.8 mL）；MICT：+170.5 mL（86.7-254.4 mL）；p<0001）和会话持续时间（HIIT：35.0 分钟（31.7 ‒） 35.6 分钟）；MICT：46.5 分钟（40.2-48.3 分钟）；p<0.001）。收缩压无明显变化，观察到高密度脂蛋白胆固醇、甘油三酯、血糖或血浆胰岛素。结论在肥胖的健康成人中，与 MICT 相比，HIIT 可诱导相似的体重减轻和心血管危险因素的改善，但导致心肺健康在更短的时间内有更大的提高。可应合理要求提供数据。