The function of biological tissues in health and disease is regulated at cellular level and is highly influenced by the physical microenvironment, through the interaction of forces between cells and ECM, which are perceived through mechanosensing pathways. In cancer, both chemical and physical signaling cascades and their interactions are involved during cell-cell and cell-ECM communications to meet requirements of tumor growth. Among stroma cells, cancer associated fibroblasts (CAFs) play key role in tumor growth and pave the way for cancer cells to initiate metastasis and invasion to other tissues, and without recruitment of CAFs, the process of cancer invasion is dysfunctional. This is through an intense chemical and physical cross talks with tumor cells, and interactive remodeling of ECM. During such interaction CAFs apply traction forces and depending on the mechanical properties, deform ECM and in return receive physical signals from the micromechanical environment. Such interaction leads to ECM remodeling by manipulating ECM structure and its mechanical properties. The results are in form of deposition of extra fibers, stiffening, rearrangement and reorganization of fibrous structure, and degradation which are due to a complex secretion and expression of different markers triggered by mechanosensing of tumor cells, specially CAFs. Such events define cancer progress and invasion of cancer cells.

A systemic knowledge of chemical and physical factors provides a holistic view of how cancer process and enhances the current treatment methods to provide more diversity among targets that involves tumor cells and ECM structure.

生物组织在健康和疾病中的功能在细胞水平上受到调节，并且受到物理微环境的高度影响，通过细胞和 ECM 之间的力相互作用，通过机械传感途径感知。在癌症中，化学和物理信号级联及其相互作用都涉及细胞-细胞和细胞-ECM 通信，以满足肿瘤生长的要求。在基质细胞中，癌相关成纤维细胞（CAFs）在肿瘤生长中起关键作用，为癌细胞开始转移和侵袭其他组织铺平了道路，如果没有 CAFs 的募集，癌症侵袭的过程就会功能失调。这是通过与肿瘤细胞进行激烈的化学和物理交叉对话，以及 ECM 的交互重塑。在这种相互作用期间，CAF 施加牵引力，并根据机械特性，使 ECM 变形，并反过来从微机械环境接收物理信号。这种相互作用通过操纵 ECM 结构及其机械性能导致 ECM 重塑。结果表现为额外纤维的沉积、纤维结构的硬化、重排和重组以及降解，这是由于肿瘤细胞机械感应触发的不同标记物的复杂分泌和表达，特别是 CAF。这些事件定义了癌症的进展和癌细胞的侵袭。结果表现为额外纤维的沉积、纤维结构的硬化、重排和重组以及降解，这是由于肿瘤细胞机械感应触发的不同标记物的复杂分泌和表达，特别是 CAF。这些事件定义了癌症的进展和癌细胞的侵袭。结果表现为额外纤维的沉积、纤维结构的硬化、重排和重组以及降解，这是由于肿瘤细胞机械感应触发的不同标记物的复杂分泌和表达，特别是 CAF。这些事件定义了癌症的进展和癌细胞的侵袭。

化学和物理因素的系统知识提供了癌症如何处理和增强当前治疗方法的整体视图，以提供涉及肿瘤细胞和 ECM 结构的靶标之间的更多多样性。