The synthesis of some new heterocyclic derivatives comprising imidazothaidiazole, diaryl ketone and chromen as starting compound has been reported. The new series of chromen analogues have been synthesized. The reaction has been monitored by Thin Layer Chromatography (TLC) using suitable mobile phase. The Rf values have been compared and the melting points of derivatives determined. Further, these derivatives have been characterized and confirmed by IR, 1H NMR and mass spectral (MS) studies. All the selected compounds submitted to National Cancer Institute (NCI) for in vitro anticancer assay have been evaluated for their anticancer activity.

中文翻译：

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作为潜在抗癌剂的新型 2,2-二甲基-2H-色烯衍生物的合成

报道了以咪唑并噻二唑、二芳基酮和色烯为起始化合物合成一些新的杂环衍生物。新系列的色氨酸类似物已经合成。使用合适的流动相通过薄层色谱法 (TLC) 监测反应。已经比较了 Rf 值并确定了衍生物的熔点。此外，这些衍生物已通过 IR、1H NMR 和质谱 (MS) 研究进行表征和确认。提交给美国国家癌症研究所 (NCI) 进行体外抗癌试验的所有选定化合物均已评估其抗癌活性。