This work aimed to explore the effects of image mosaic algorithm- (IMA-) based low-dose X-rays on deoxyribonucleic acid (DNA) damage of peripheral blood lymphocytes in cardiovascular patients. 84 patients with interventional cardiovascular surgeries were selected as the research objects and divided into coronary intervention surgery (A) group, coronary angiography (B) group, radiofrequency ablation (C) group, and permanent cardiac pacemaker implantation (D) group. They were treated with IMA-based low-dose X-rays, DNA damage indicators of lymphocytes were detected, and the relationship was analyzed between those indicators and radiation dose. Results showed that the cumulative dose (CD) and dose area product (DAP) of group A were the lowest, and those of group D were obviously higher than those of the other three groups (). Besides, the results also showed that the values of CD and DAP of patients from group A and group D were 0.38 ± 0.08 (Gy) and 0.38 ± 0.08 (Gy/cm²) and 1.37 ± 0.21 (Gy) and 1.37 ± 0.21(Gy/cm²), respectively. The comet tail DNA content (TDNA) and tail moment (TM) of each group after surgery increased dramatically compared with before surgery (), and the TDNA and TM of group D were greatly higher than those of the other three groups (). Therefore, TDNA and TM were markedly positively correlated with DAP and CD (). IMA-based X-ray radiotherapy caused reliable DNA damage to peripheral blood lymphocytes of cardiovascular patients, and the greater the radiation dose, the more serious the DNA damage.

中文翻译：

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基于图像拼接算法的低剂量 X 射线对血液免疫细胞影响的分析

本工作旨在探讨基于图像拼接算法（IMA-）的低剂量X射线对心血管患者外周血淋巴细胞脱氧核糖核酸（DNA）损伤的影响。选取84例心血管介入手术患者为研究对象,分为冠状动脉介入手术(A)组、冠状动脉造影(B)组、射频消融(C)组、永久性心脏起搏器植入(D)组。对他们进行基于IMA的低剂量X射线治疗，检测淋巴细胞的DNA损伤指标，并分析这些指标与辐射剂量之间的关系。结果显示，A组累积剂量（CD）和剂量面积乘积（DAP）最低，D组明显高于其他三组（）。此外，结果还显示，A组和D组患者的CD和DAP值分别为0.38±0.08（Gy）和0.38±0.08（Gy/cm ²）和1.37±0.21（Gy）和1.37±0.21（Gy）。 Gy/cm ² )，分别。术后各组彗尾DNA含量（TDNA）和尾矩（TM）较术前显着增加（)， D组的TDNA和TM明显高于其他三组(）。因此，TDNA 和 TM 与 DAP 和 CD 呈显着正相关（）。基于 IMA 的 X 射线放疗对心血管患者外周血淋巴细胞造成可靠的 DNA 损伤，且辐射剂量越大，DNA 损伤越严重。