Acral melanoma (AM) arises on the palms, soles and nail apparatus (subungual), and remains a major health problem with poor prognosis and advanced pathology at the time of diagnosis (Durbec et al., 2012). AM is distinct from melanoma arising on the sun-exposed dorsal skin of the hands and feet (Haugh et al., 2018). Most melanoma research has focused on melanomas on sun-exposed sites. Further, little is known about the clinical and pathological features of AM in the African context. The primary objective of this study was to describe the clinical and histopathological features of a series of South African AMs.

中文翻译：

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一系列南非肢端黑色素瘤的临床病理学特征和关联

肢端黑色素瘤 (AM) 出现在手掌、脚底和指甲装置（甲下），并且在诊断时仍然是预后不良和晚期病理学的主要健康问题（Durbec 等，2012）。AM 不同于出现在暴露在阳光下的手脚背侧皮肤上的黑色素瘤（Haugh 等人，2018 年）。大多数黑色素瘤研究都集中在阳光照射部位的黑色素瘤上。此外，关于非洲背景下 AM 的临床和病理特征知之甚少。本研究的主要目的是描述一系列南非 AMs 的临床和组织病理学特征。