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Insight into the fluoroquinolone resistance, sources, ecotoxicity, and degradation with special emphasis on ciprofloxacin
Journal of Water Process Engineering ( IF 7 ) Pub Date : 2021-07-19 , DOI: 10.1016/j.jwpe.2021.102218
Kushneet Kaur Sodhi 1 , Dileep Kumar Singh 1
Affiliation  

The presence of antibiotics in wastewater, domestic water, and sewage has been found to produce ecotoxicological effects on living beings. Fluoroquinolones (FQs) are recognized as critically important and highly prioritized antimicrobial and are frequently used in veterinary and human medicine. The recalcitrance of these antibiotics along with their poor metabolism has led to their detection in manures and wastewater. Ciprofloxacin (CIP) is a synthetic and commonly prescribed FQ and the metabolite of enrofloxacin, the veterinary drug. CIP has negative effects on the flora and fauna. Due to the emergence of bacterial resistance against FQs, special attention is given to the environmental degradation of these antibiotics by microorganisms. Physicochemical processes and bioremediation are employed for the removal of CIP, but the lipophilic and hydrophobic nature of the antibiotics acts as a hindrance to their complete removal from the environment. The present review gives an insight into the sources of FQs in the environment, their detection, and their impact on living beings. CIP removal is being paid special attention and recent trends in its removal are discussed.



中文翻译:

深入了解氟喹诺酮类药物的耐药性、来源、生态毒性和降解,特别强调环丙沙星

已发现废水、生活用水和污水中抗生素的存在会对生物产生生态毒理学影响。氟喹诺酮类药物 (FQ) 被认为是极其重要和高度优先的抗菌药物,经常用于兽医和人类医学。这些抗生素的顽固性以及它们的不良代谢导致它们在粪便和废水中被检测到。环丙沙星 (CIP) 是一种合成的常用处方 FQ,是兽药恩诺沙星的代谢物。CIP 对动植物有负面影响。由于细菌对 FQs 的耐药性的出现,微生物对这些抗生素的环境降解给予了特别关注。物理化学过程和生物修复用于去除 CIP,但抗生素的亲脂性和疏水性阻碍了它们从环境中完全清除。本综述深入了解了环境中 FQ 的来源、它们的检测以及它们对生物的影响。CIP 去除受到特别关注,并讨论了其去除的最新趋势。

更新日期:2021-07-20
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