Previous work in Huntington’s disease (HD) has shown that a sense of meaning and purpose (M&P) is positively associated with positive affect and well-being (PAW); however, it was unknown whether HD-validated patient-reported outcomes (PROs) influence this association and how M&P impacts PROs in the future. Our study was designed to examine if HD-validated PROs moderate the relationship between M&P and PAW and to evaluate if baseline M&P predicts 12- and 24-month changes in HD-validated PROs.

中文翻译：

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亨廷顿病的意义和目的：对生活质量影响的纵向研究

亨廷顿病 (HD) 的先前研究表明，意义感和目的感 (M&P) 与积极情感和幸福感 (PAW) 呈正相关；然而，尚不清楚 HD 验证的患者报告结果 (PROs) 是否会影响这种关联，以及 M&P 在未来如何影响 PROs。我们的研究旨在检查 HD 验证的 PROs 是否调节 M&P 和 PAW 之间的关系，并评估基线 M&P 是否预测 HD 验证的 PROs 的 12 个月和 24 个月的变化。