As a potential treatment for epilepsy, transcutaneous auricular vagus nerve stimulation (taVNS) has yielded inconsistent results. Combining transcranial magnetic stimulation with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) can be used to investigate the effect of interventions on cortical excitability by evaluating changes in motor evoked potentials (MEPs) and TMS-evoked potentials (TEPs). The goal of this study is to objectively evaluate the effect of taVNS on cortical excitability with TMS-EMG and TMS-EEG. These findings are expected to provide insight in the mechanism of action and help identify more optimal stimulation paradigms.

中文翻译：

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研究经皮耳迷走神经刺激对健康男性皮质兴奋性的影响

作为癫痫的潜在治疗方法，经皮耳迷走神经刺激（taVNS）产生了不一致的结果。将经颅磁刺激与肌电图 (TMS-EMG) 和脑电图 (TMS-EEG) 相结合，可通过评估运动诱发电位 (MEP) 和 TMS 诱发电位 (TEP) 的变化来研究干预措施对皮质兴奋性的影响。本研究的目的是通过 TMS-EMG 和 TMS-EEG 客观评估 taVNS 对皮质兴奋性的影响。这些发现有望提供对作用机制的深入了解，并帮助确定更优化的刺激范例。