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BDNF rs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease
Neuromodulation: Technology at the Neural Interface ( IF 3.2 ) Pub Date : 2021-07-20 , DOI: 10.1111/ner.13504 Caryl E Sortwell 1 , Mallory L Hacker 2 , David Luke Fischer 3 , Peter E Konrad 4 , Thomas L Davis 2 , Joseph S Neimat 4 , Lily Wang 5 , Yanna Song 5 , Zach R Mattingly 3 , Allyson Cole-Strauss 3 , Jack W Lipton 1 , P David Charles 2
Neuromodulation: Technology at the Neural Interface ( IF 3.2 ) Pub Date : 2021-07-20 , DOI: 10.1111/ner.13504 Caryl E Sortwell 1 , Mallory L Hacker 2 , David Luke Fischer 3 , Peter E Konrad 4 , Thomas L Davis 2 , Joseph S Neimat 4 , Lily Wang 5 , Yanna Song 5 , Zach R Mattingly 3 , Allyson Cole-Strauss 3 , Jack W Lipton 1 , P David Charles 2
Affiliation
The efficacy of pharmacotherapy and deep brain stimulation of the subthalamic nucleus in treating Parkinson's disease motor symptoms is highly variable and may be influenced by patient genotype. The relatively common (prevalence about one in three) and protein-altering rs6265 single nucleotide polymorphism (C > T) in the gene BDNF has been associated with different clinical outcomes with levodopa.
中文翻译：
BDNF rs6265 基因型影响早期帕金森病药物治疗和丘脑底核深部脑刺激的结果
药物治疗和丘脑底核深部脑刺激治疗帕金森病运动症状的疗效差异很大，并且可能受到患者基因型的影响。BDNF基因中相对常见（患病率约为三分之一）且改变蛋白质的 rs6265 单核苷酸多态性 (C > T)与左旋多巴的不同临床结果相关。
更新日期：2021-07-20
中文翻译：
BDNF rs6265 基因型影响早期帕金森病药物治疗和丘脑底核深部脑刺激的结果
药物治疗和丘脑底核深部脑刺激治疗帕金森病运动症状的疗效差异很大，并且可能受到患者基因型的影响。BDNF基因中相对常见（患病率约为三分之一）且改变蛋白质的 rs6265 单核苷酸多态性 (C > T)与左旋多巴的不同临床结果相关。
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