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Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2021-07-19 , DOI: 10.1002/cti2.1312
Sophia Hober 1 , Cecilia Hellström 2 , Jennie Olofsson 2 , Eni Andersson 2 , Sofia Bergström 2 , August Jernbom Falk 2 , Shaghayegh Bayati 2 , Sara Mravinacova 2 , Ronald Sjöberg 2 , Jamil Yousef 2 , Lovisa Skoglund 2 , Sara Kanje 1 , Anna Berling 1 , Anne-Sophie Svensson 1 , Gabriella Jensen 1 , Henric Enstedt 1 , Delaram Afshari 1 , Lan Lan Xu 1 , Martin Zwahlen 3 , Kalle von Feilitzen 3 , Leo Hanke 4 , Ben Murrell 4 , Gerald McInerney 4 , Gunilla B Karlsson Hedestam 4 , Christofer Lendel 5 , Robert G Roth 6 , Ingmar Skoog 7 , Elisabet Svenungsson 8 , Tomas Olsson 9 , Anna Fogdell-Hahn 9 , Ylva Lindroth 10 , Maria Lundgren 11 , Kimia T Maleki 12, 13 , Nina Lagerqvist 13 , Jonas Klingström 12, 13 , Rui Da Silva Rodrigues 14 , Sandra Muschiol 15 , Gordana Bogdanovic 15 , Laila Sara Arroyo Mühr 16 , Carina Eklund 17 , Camilla Lagheden 17 , Joakim Dillner 17 , Åsa Sivertsson 1 , Sebastian Havervall 18 , Charlotte Thålin 18 , Hanna Tegel 1 , Elisa Pin 2 , Anna Månberg 2 , My Hedhammar 1 , Peter Nilsson 2
Affiliation  

The COVID-19 pandemic poses an immense need for accurate, sensitive and high-throughput clinical tests, and serological assays are needed for both overarching epidemiological studies and evaluating vaccines. Here, we present the development and validation of a high-throughput multiplex bead-based serological assay.

中文翻译:

对 SARS-CoV-2 抗原的系统评估可实现高度特异性和灵敏的多重血清学 COVID-19 检测

COVID-19 大流行对准确、敏感和高通量的临床测试提出了巨大的需求,而且总体流行病学研究和疫苗评估都需要血清学检测。在这里,我们介绍了基于高通量多重珠的血清学检测的开发和验证。
更新日期:2021-07-20
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