Ir(III)-Catalyzed and Ag2O-Promoted C−H/C−H Cross-Coupling/Intramolecular Cyclization of Ketene Dithioacetals with Benzothiophene,Advanced Synthesis & Catalysis

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Ir(III)-Catalyzed and Ag2O-Promoted C−H/C−H Cross-Coupling/Intramolecular Cyclization of Ketene Dithioacetals with Benzothiophene
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-07-19 , DOI: 10.1002/adsc.202100682
Jinkang Chen ₁ , Chuanliu Yin ₂ , Jian Zhou ₂ , Chuanming Yu _{1,

2}

Affiliation

A tandem Ir(III)-catalyzed and Ag₂O-promoted cross-dehydrogenative coupling (CDC)/ intramolecular cyclization of ketene dithioacetals with benzothiophene derivatives was developed, affording a series of sulfur-containing cyclization compounds. Mechanistic investigation demonstrated a radical process may be involving intramolecular cyclization. This tandem reaction described herein could be carried out with a broad range of substrates and wide functional group tolerance.

中文翻译：

Ir(III)-催化和 Ag2O 促进的 C−H/C−H 交叉偶联 / 乙烯酮二硫缩醛与苯并噻吩的分子内环化

开发了串联 Ir(III) 催化和 Ag ₂ O 促进的交叉脱氢偶联 (CDC)/乙烯酮二硫缩醛与苯并噻吩衍生物的分子内环化，得到了一系列含硫环化化合物。机理研究表明，一个激进的过程可能涉及分子内环化。本文描述的这种串联反应可以用广泛的底物和广泛的官能团耐受性进行。

更新日期：2021-09-21

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