SARS-CoV-2 infections in pregnant women and the consequences for their offspring are summarised in various reviews,1 2 but data on the impact of time of SARS-CoV-2 infection during pregnancy on neonatal morbidity are still inconclusive.3 4 CRONOS (COVID-19-Related Obstetric and Neonatal Outcome Study) is a prospective German registry enrolling pregnant women with confirmed SARS-CoV-2 infection during their pregnancy.5 SARS-CoV-2 infection is defined as detection of viral RNA by PCR testing or detection of maternal SARS-CoV-2 antibodies. Neonatal infection is defined as detection of viral RNA by PCR testing of a nasopharyngeal/oropharyngeal or rectal swab. For the present analysis, time of maternal infection was categorised into ‘early’ or ‘late’ if women tested positive for SARS-CoV-2 more or less than 2 weeks prior to delivery, respectively. Data obtained between 3 April and 27 November 2020 were analysed, using 74 hospitals (73 German and 1 Austrian) comprising approximately 20% of German births. Within the study period 435 newborns were entered into the registry, 4 …

中文翻译：

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德国产妇感染 SARS-CoV-2 后的新生儿结局：COVID-19 相关产科和新生儿结局研究 (CRONOS)

多篇综述总结了孕妇感染 SARS-CoV-2 及其对其后代的影响，1 2 但有关怀孕期间 SARS-CoV-2 感染时间对新生儿发病率影响的数据仍无定论。 3 4 CRONOS ( COVID-19-Related Obstetric and Neonatal Outcome Study) 是一项前瞻性的德国注册登记，招募在怀孕期间确诊感染 SARS-CoV-2 的孕妇。 5 SARS-CoV-2 感染定义为通过 PCR 检测或检测检测到病毒 RNA母体 SARS-CoV-2 抗体。新生儿感染定义为通过鼻咽/口咽或直肠拭子的 PCR 检测检测到病毒 RNA。对于目前的分析，如果妇女在分娩前多于或少于 2 周分别检测出 SARS-CoV-2 呈阳性，则将母体感染时间分为“早期”或“晚期”。对 2020 年 4 月 3 日至 11 月 27 日期间获得的数据进行了分析，使用了 74 家医院（73 家德国和 1 家奥地利），约占德国出生的 20%。在研究期间，有 435 名新生儿进入登记处，4…