Objectives We investigated haemodynamics and clinical outcomes according to type of pulmonary hypertension (PH) in patients with constrictive pericarditis (CP). Background As the prevalence of CP with concomitant myocardial disease (mixed CP) grows, PH is more commonly seen in patients with CP. However, haemodynamic and outcome data according to the presence or absence of PH are limited. Methods 150 patients with surgically confirmed CP who underwent echocardiography and cardiac catheterisation within 7 days at two tertiary centres were divided into three groups: no-PH, isolated postcapillary PH (Ipc-PH) and combined postcapillary and precapillary PH (Cpc-PH). Primary outcome was all-cause mortality during follow-up. Result In this retrospective cohort study, 110 (73.3%) had PH (mean pulmonary artery pressure ≥25 mm Hg). Cpc-PH, using defined cut-offs for pulmonary vascular resistance (>3 Wood units) or diastolic pulmonary gradient (≥7 mm Hg), was seen in 18 patients (12%). The Cpc-PH group had a higher prevalence of comorbidities (diabetes and atrial fibrillation) and concomitant myocardial disease as an aetiology of CP than other groups. Pulmonary vascular resistance had a significant direct correlation with medial E/e′ by Doppler echocardiography ( r =0.404, p<0.001). Survival rate was significantly lower in the Cpc-PH than the no-PH (p=0.002) and Ipc-PH (p=0.024) groups. On multivariable analysis, age, New York Heart Association functional class IV, medial e′ velocity, Cpc-PH and Ipc-PH were independently associated with long-term mortality. Conclusion Combined postcapillary and precapillary PH develops in a subset of patients with CP and is associated with long-term mortality after pericardiectomy. No data are available. Due to privacy and ethical concerns, neither the data nor the source of the data can be made available.

中文翻译：

---

缩窄性心包炎患者肺动脉高压的临床意义

目的 我们根据缩窄性心包炎 (CP) 的肺动脉高压 (PH) 类型研究了血流动力学和临床结果。背景 随着 CP 合并心肌疾病（混合 CP）的患病率增加，PH 更常见于 CP 患者。然而，根据存在或不存在 PH 的血液动力学和结果数据是有限的。方法 将 150 例手术确诊的 CP 患者在 7 天内在两个三级中心接受超声心动图和心导管插入术分为三组：无 PH、孤立性毛细血管后 PH（Ipc-PH）和毛细血管后和毛细血管前联合 PH（Cpc-PH）。主要结局是随访期间的全因死亡率。结果 在这项回顾性队列研究中，110 人 (73.3%) 患有 PH（平均肺动脉压≥25 mmHg）。Cpc-PH, 在 18 名患者 (12%) 中观察到使用定义的肺血管阻力（> 3 Wood 单位）或舒张肺梯度（≥ 7 mm Hg）的临界值。与其他组相比，Cpc-PH 组的合并症（糖尿病和心房颤动）和伴随的作为 CP 病因的心肌疾病的患病率更高。肺血管阻力与多普勒超声心动图显示的内侧 E/e' 具有显着的直接相关性（r =0.404，p<0.001）。Cpc-PH 组的存活率显着低于无 PH (p=0.002) 和 Ipc-PH (p=0.024) 组。在多变量分析中，年龄、纽约心脏协会功能分级 IV、内侧 e' 速度、Cpc-PH 和 Ipc-PH 与长期死亡率独立相关。结论 毛细血管后和毛细血管前联合 PH 在 CP 患者亚组中发生，并且与心包切除术后的长期死亡率相关。没有可用数据。由于隐私和道德问题，我们无法提供数据和数据来源。