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Blood Glucose and Renal Function Evaluation in Patients with Viral Hepatitis
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy ( IF 2.8 ) Pub Date : 2021-07-20 , DOI: 10.2147/dmso.s303252 Wen-Tung Hsu , Deng-Ho Yang , Chun-Cheng Liao , Chen Jia-Wen , Wen-Hsiu Hsu , Chia-Wen Kuo , Hung-Chang Hsu , Sheng-Huang Chang , Li-Mien Chen
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy ( IF 2.8 ) Pub Date : 2021-07-20 , DOI: 10.2147/dmso.s303252 Wen-Tung Hsu , Deng-Ho Yang , Chun-Cheng Liao , Chen Jia-Wen , Wen-Hsiu Hsu , Chia-Wen Kuo , Hung-Chang Hsu , Sheng-Huang Chang , Li-Mien Chen
Purpose: To evaluate the blood glucose and renal function, determine the prevalence of hyperglycemia/diabetes mellitus (DM) and renal disease (nephropathy), and investigate the association between hyperglycemia/DM and renal disease in patients with viral hepatitis (VH).
Patients and Methods: A total of 491 subjects were included in the study. Patients with VH were further divided into the hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, and HBV-HCV co-infection subgroups. Fasting blood glucose, glycated hemoglobin (HbA1c), glycated albumin (GA), glutamic oxaloacetic transaminase (GOT), creatinine (Cr), and cystatin C (Cys C) levels were measured. Urine microalbumin levels were also assessed. Formulas for estimated average glucose calculated using glycated albumin(eAG(GA)), estimated average glucose calculated using HbA1c (eAG(HbA1c)), and estimated glomerular filtration rate calculated using cystatin C (eGFRcys) were used to evaluate the average glucose and renal function.
Results: The prevalence of hyperglycemia/DM and renal disease was significantly higher in the VH group, especially in the HCV subgroup. The prevalence of renal disease was significantly higher in patients with VH with eAG(GA) ≥ 200 mg/dL.
Conclusion: Our study used multiple parameters to evaluate blood glucose and renal function in patients with VH and found that hyperglycemia/DM and renal disease are closely associated with VH, especially in subjects with HCV infection. Patients with VH, especially those with HCV infection and hyperglycemia/DM, were particularly vulnerable to renal disease.
Keywords: viral hepatitis, hyperglycemia, diabetes mellitus, renal disease, nephropathy
中文翻译：
病毒性肝炎患者的血糖和肾功能评估
目的：评估病毒性肝炎（VH）患者的血糖和肾功能，确定高血糖/糖尿病（DM）和肾脏疾病（肾病）的患病率，并研究高血糖/DM与肾脏疾病之间的关系。
患者和方法：共有 491 名受试者被纳入研究。VH患者进一步分为乙型肝炎病毒（HBV）感染、丙型肝炎病毒（HCV）感染和HBV-HCV共感染亚组。测量空腹血糖、糖化血红蛋白 (HbA1c)、糖化白蛋白 (GA)、谷氨酸草酰乙酸转氨酶 (GOT)、肌酐 (Cr) 和胱抑素 C (Cys C) 水平。还评估了尿液微量白蛋白水平。使用糖化白蛋白 (eAG(GA)) 计算的估计平均葡萄糖公式、使用 HbA1c 计算的估计平均葡萄糖 (eAG(HbA1c)) 和使用胱抑素 C (eGFRcys) 计算的估计肾小球滤过率公式用于评估平均葡萄糖和肾功能。
结果：VH 组的高血糖/DM 和肾脏疾病的患病率显着较高，尤其是在 HCV 亚组中。eAG(GA) ≥ 200 mg/dL 的 VH 患者肾病患病率显着升高。
结论：我们的研究使用多个参数来评估 VH 患者的血糖和肾功能，发现高血糖/DM 和肾脏疾病与 VH 密切相关，尤其是在 HCV 感染的受试者中。VH 患者，尤其是 HCV 感染和高血糖/DM 患者，特别容易患肾病。
【关键词】：病毒性肝炎 高血糖 糖尿病 肾病 肾病
更新日期：2021-07-20
Patients and Methods: A total of 491 subjects were included in the study. Patients with VH were further divided into the hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, and HBV-HCV co-infection subgroups. Fasting blood glucose, glycated hemoglobin (HbA1c), glycated albumin (GA), glutamic oxaloacetic transaminase (GOT), creatinine (Cr), and cystatin C (Cys C) levels were measured. Urine microalbumin levels were also assessed. Formulas for estimated average glucose calculated using glycated albumin(eAG(GA)), estimated average glucose calculated using HbA1c (eAG(HbA1c)), and estimated glomerular filtration rate calculated using cystatin C (eGFRcys) were used to evaluate the average glucose and renal function.
Results: The prevalence of hyperglycemia/DM and renal disease was significantly higher in the VH group, especially in the HCV subgroup. The prevalence of renal disease was significantly higher in patients with VH with eAG(GA) ≥ 200 mg/dL.
Conclusion: Our study used multiple parameters to evaluate blood glucose and renal function in patients with VH and found that hyperglycemia/DM and renal disease are closely associated with VH, especially in subjects with HCV infection. Patients with VH, especially those with HCV infection and hyperglycemia/DM, were particularly vulnerable to renal disease.
Keywords: viral hepatitis, hyperglycemia, diabetes mellitus, renal disease, nephropathy
中文翻译：
病毒性肝炎患者的血糖和肾功能评估
目的：评估病毒性肝炎（VH）患者的血糖和肾功能，确定高血糖/糖尿病（DM）和肾脏疾病（肾病）的患病率，并研究高血糖/DM与肾脏疾病之间的关系。
患者和方法：共有 491 名受试者被纳入研究。VH患者进一步分为乙型肝炎病毒（HBV）感染、丙型肝炎病毒（HCV）感染和HBV-HCV共感染亚组。测量空腹血糖、糖化血红蛋白 (HbA1c)、糖化白蛋白 (GA)、谷氨酸草酰乙酸转氨酶 (GOT)、肌酐 (Cr) 和胱抑素 C (Cys C) 水平。还评估了尿液微量白蛋白水平。使用糖化白蛋白 (eAG(GA)) 计算的估计平均葡萄糖公式、使用 HbA1c 计算的估计平均葡萄糖 (eAG(HbA1c)) 和使用胱抑素 C (eGFRcys) 计算的估计肾小球滤过率公式用于评估平均葡萄糖和肾功能。
结果：VH 组的高血糖/DM 和肾脏疾病的患病率显着较高，尤其是在 HCV 亚组中。eAG(GA) ≥ 200 mg/dL 的 VH 患者肾病患病率显着升高。
结论：我们的研究使用多个参数来评估 VH 患者的血糖和肾功能，发现高血糖/DM 和肾脏疾病与 VH 密切相关，尤其是在 HCV 感染的受试者中。VH 患者，尤其是 HCV 感染和高血糖/DM 患者，特别容易患肾病。
【关键词】：病毒性肝炎 高血糖 糖尿病 肾病 肾病
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