Genome-wide association studies have identified genetic variants in maternal and fetal genomes associated with early-life growth traits but have been limited by the paucity of large-scale family-based cohorts that would enable the resolution of informative transmissions between parents and their offspring. A new study uses extensive pedigree data from the Icelandic population to identify genetic effects on birth weight that differ according to parental origin and to demarcate distinct contributions from the maternal intrauterine environment and offspring genetics on fetal growth.

中文翻译：

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揭示胎儿生长的遗传学

全基因组关联研究已经确定了与生命早期生长特征相关的母体和胎儿基因组中的遗传变异，但由于缺乏能够解决父母与其后代之间信息传递的大规模家庭群体，因此受到限制。一项新的研究利用来自冰岛人口的广泛谱系数据来确定不同父母来源对出生体重的遗传影响，并区分母亲宫内环境和后代遗传对胎儿生长的不同贡献。