Rad54 and Rdh54 are Snf2 DNA motor proteins that function during maintenance of genomic integrity. Though highly related, Rad54 and Rdh54 have different biochemical and genetic functions during maintenance of genomic integrity. Rad54 functions primarily during the homology search and strand invasion steps of homologous recombination, while Rdh54 appears to play a minor role in these processes. More recently it has been shown that Rdh54 functions as a pathway branch point at HR intermediates, and as has a role in cell cycle recovery. Here we will explore recent advances that have improved our understanding of the role these two DNA motor proteins play during DNA repair.

Rad54 和 Rdh54 是 Snf2 DNA 运动蛋白，在维持基因组完整性期间发挥作用。虽然高度相关，但 Rad54 和 Rdh54 在维持基因组完整性期间具有不同的生化和遗传功能。Rad54 主要在同源重组的同源搜索和链侵入步骤中起作用，而 Rdh54 似乎在这些过程中起次要作用。最近显示，Rdh54 作为 HR 中间体的通路分支点发挥作用，并在细胞周期恢复中发挥作用。在这里，我们将探讨最近的进展，这些进展提高了我们对这两种 DNA 运动蛋白在 DNA 修复过程中所起作用的理解。