Background

Oligometastatic colorectal cancer (CRC) is potentially curable and demands individualised strategies.

Methods

This single-centre retrospective study investigated if positron emission tomography (PET)/magnetic resonance imaging (MR) had a clinical impact on oligometastatic CRC relative to the standard of care imaging (SCI). Adult patients with oligometastatic CRC on SCI who also underwent PET/MR between 3/2016 and 3/2019 were included. The exclusion criterion was lack of confirmatory standard of reference, either surgical pathology, intraoperative gross confirmation or imaging follow-up. SCI consisted of contrast-enhanced (CE) computed tomography (CT) of the chest/abdomen/pelvis, abdominal/pelvic CE-MR, and/or CE whole-body PET/CT with diagnostic quality (i.e. standard radiation dose) CT. Follow-up was evaluated until 3/2020.

Results

Thirty-one patients constituted the cohort, 16 (52%) male, median patient age was 53 years (interquartile range: 49–65 years). PET/MR and SCI results were divergent in 19% (95% CI 9–37%) of the cases, with PET/MR leading to management changes in all of them. The diagnostic accuracy of PET/MR was 90 ± 5%, versus 71 ± 8% for SCI. In a pairwise analysis, PET/MR outperformed SCI when compared to the reference standard (p = 0.0412).

Conclusions

These findings suggest the potential usefulness of PET/MR in the management of oligometastatic CRC.

中文翻译：

---

PET/MRI 对寡转移性结直肠癌的临床影响

背景

寡转移性结直肠癌 (CRC) 具有潜在可治愈性，需要个体化策略。

方法

这项单中心回顾性研究调查了正电子发射断层扫描 (PET)/磁共振成像 (MR) 相对于护理成像标准 (SCI) 是否对寡转移性 CRC 有临床影响。纳入 2016 年 3 月至 2019 年 3 月期间接受 PET/MR 的 SCI 少转移性 CRC 成年患者。排除标准是缺乏确认性参考标准，无论是手术病理学、术中大体确认还是影像学随访。SCI 包括胸部/腹部/骨盆的对比增强 (CE) 计算机断层扫描 (CT)、腹部/骨盆 CE-MR 和/或具有诊断质量（即标准辐射剂量）CT 的 CE 全身 PET/CT。随访评估至 2020 年 3 月。

结果

31 名患者构成队列，16 名（52%）男性，患者中位年龄为 53 岁（四分位距：49-65 岁）。PET/MR 和 SCI 结果在 19% (95% CI 9-37%) 的病例中存在差异，PET/MR 导致所有病例的管理变化。PET/MR 的诊断准确率为 90 ± 5%，而 SCI 为 71 ± 8%。在成对分析中，与参考标准相比，PET/MR 的表现优于 SCI ( p  = 0.0412)。

结论

这些发现表明 PET/MR 在寡转移性 CRC 管理中的潜在用途。