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Linking autoimmunity, short telomeres and lung fibrosis in SSc
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2021-07-19 , DOI: 10.1038/s41584-021-00666-3
Katja Lakota 1 , John Varga 2
Affiliation  

Short telomere length is implicated in lung diseases and can be caused by mutations in telomere genes. Acquired autoimmunity directed against components of the telomere system is now reported in some patients with systemic sclerosis or idiopathic pulmonary fibrosis, suggesting a novel explanation for short telomeres in these diseases.

中文翻译:

将自身免疫、短端粒和 SSc 中的肺纤维化联系起来

端粒长度短与肺部疾病有关,可能由端粒基因突变引起。现在在一些患有系统性硬化症或特发性肺纤维化的患者中报道了针对端粒系统成分的获得性自身免疫,这表明这些疾病中端粒短的新解释。
更新日期:2021-07-19
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