This work presents a novel methodology that combines the scattered information in the literature for the construction of residue curve maps through a global optimization technique. The synthesis of Butyl Lactate from Lactic Acid and 1-Butanol was considered as case study since this compound is increasingly used as green solvent, flavor in the food industry, and in pharmaceutical formulations. Initially, a review on reported experimental thermodynamic data for the system involved in the Butyl Lactate synthesis was done. Then, a validation of binary parameters was performed according to the NRTL activity model, which replicates properly the available information. The kinetic model of the system was validated, and the reactive curve maps were calculated at different Damköhler (Da) values. The model predicts different azeotropes at 5 and 101.325 kPa and the systems were topologically consistent according to the thermodynamic evaluation. Based on the analysis of residue curve maps, Butyl Lactate can be obtained in the bottom stream. Finally, a conceptual design to produce Butyl Lactate by reactive distillation was proposed by using the generated residue maps.

这项工作提出了一种新颖的方法，该方法结合了文献中的分散信息，用于通过全局优化技术构建残留曲线图。从乳酸和 1-丁醇合成乳酸丁酯被视为案例研究，因为该化合物越来越多地用作绿色溶剂、食品工业和药物制剂中的调味剂。最初，对涉及乳酸丁酯合成的系统的报告实验热力学数据进行了审查。然后，根据 NRTL 活动模型对二元参数进行验证，该模型正确复制了可用信息。验证了系统的动力学模型，并在不同的 Damköhler (Da) 值下计算了反应曲线图。该模型预测了 5 和 101 的不同共沸物。根据热力学评估，325 kPa 和系统在拓扑上是一致的。根据残留曲线图的分析，可以在底部流中获得乳酸丁酯。最后，通过使用生成的残留图提出了通过反应蒸馏生产乳酸丁酯的概念设计。